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Join us at BIYSC! Understanding the clues of cell construction in eukaryotes

By  Josep M. Fernández-Novell (Prof. at University of Barcelona (UB) Faculty of Biology – Biochemistry and Molecular Biology Department), BIYSC Coordinator of the project “Biogenesis of endoplasmic reticulum and its relevance in the eukaryotic cell pathologies

biysc_ub_2016_2Eukaryotic HMG-CoA reductase (HMGR) has a key regulatory role in the synthesis of many essential compounds as sterols, hormones and other products that control growth and development.

In addition, HMGR has a now emerging role in the biogenesis of the endoplasmic reticulum (ER). Expression of the membrane domain of HMGR in yeast, plant or mammalian cells induces proliferation and accumulation of ER membranes that, at the electron microscope, are visualized as stacked membranes, concentric membrane associations or ordered arrays of membranes with hexagonal or cubic symmetry. These structures have been collectively named organized smooth ER (OSER).

At BIYSC, the students will characterize the morphogenesis of the ER driven by HMGR in the plant Arabidopsis thaliana, used as a model system. Mutants defective in HMGR or transgenic plants over-expressing the membrane domain of HMGR fused to GFP (green fluorescent protein) will be identified in genotyping studies by Polymerase Chain Reaction (PCR). These plants will be submitted to stereoscopic, confocal and electron microscopy analyses, to examine the effect of the absence or over-expression of HMGR in the morphogenesis of the ER and, particularly, in the biogenesis of OSER structures.

UB Universitat de Barcelona

Join us at BIYSC! APPLY NOW!

biysc_ub logo_2BIYSC is an International Scientific Challenge programme, that aims to connect the most passionate science students with the best researchers in their field. Registrations are open, do not lose your place! If you like science and you are between 16-19 years-old you cannot miss BIYSC from July 11th to 22nd 2016 in ‪#‎Barcelona! 10 projects, 10 ‪#‎research centers, two weeks of practical courses to work in research centers side-by-side with researchers, ‪#‎scientific conferences, debates, visits to the research centers and much more! Are you in? www.biysc.org

The University of Barcelona (UB) is the most formidable public institution of higher education in Catalonia, catering to the needs of the greatest number of students and delivering the broadest and most comprehensive offering in higher educational courses. The UB is also the principal centre of university research in Spain and has become a European benchmark for research activity, both in terms of the number of research programmes it conducts and the excellence these have achieved. The Faculty of Biology is located on the UB Pedralbes Campus opposite the Palau Reial, and as such is well connected with the various public transport systems in the metropolitan area. The three basic functions of the Faculty are teaching (transmitting knowledge), research (generating knowledge) and interaction with society (encouraging research development).

Director of the Biochemistry and Molecular Biology Department (University of Barcelona (UB) Faculty of Biology-): Javier Casado  Renowed Researcher: Narciso Campos

biysc _research centers and collaborations 2016

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Contact us: contact@biysc.org or groups@biysc.org

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